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The box
Retatrutide
Injector pen9 mg, 14 mg, 19 mg, 29 mg
From $24 per week as a VIP member
What users report
Satiety comes back
Up to a quarter of body weight lost
A curve that keeps going down
Less fat in the liver
Hunger that settles within the first days, according to users, and meals that become a choice again rather than a struggle.
Satiety comes back
It activates the GLP-1 and GIP receptors, those of appetite and satiety, and users report quieter hunger within the first days.
Up to a quarter of body weight lost
In the phase 3 trial TRIUMPH-1, in 2,339 adults, average loss reached 25% of starting weight, against 3.9% on placebo.
A curve that keeps going down
In phase 2, weight was still falling at the last measurement: no plateau had been reached.
Less fat in the liver
Up to 82% less liver fat, measured by MRI (Nature Medicine, 2024).
Documented in humans
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People choose it for weight loss: up to 28.7% of body weight on average in the TRIUMPH-4 phase 3 trial.
What it is: A triple agonist: one molecule activates three receptors, GLP-1 and GIP for appetite and satiety, glucagon for energy expenditure.
Documented in humans
Up to 28.7% of body weight on average in a phase 3 trial: for a 250 lb person, that is more than 70 lb.
One molecule, three receptors: GLP-1 and GIP for appetite and satiety, glucagon for energy expenditure.
Why people choose it:
- Weight loss: 25% on average at the highest dose in TRIUMPH-1, the largest phase 3 study (2,339 adults).
- Appetite: users report hunger dropping within the first days.
- Loss that keeps going: in phase 2, the weight curve was still falling at the last measurement.
- Liver fat: up to 82% less, measured by MRI (Nature Medicine, 2024).
- Blood sugar: a larger drop in HbA1c than with dulaglutide (The Lancet, 2023).
Four phase 3 trials, TRIUMPH-1 to TRIUMPH-4: no other product in our catalogue has as many.
Level of evidence, possible effects and contraindications: see the full retatrutide profile.
30-day trial, no card: the member price from today, no commitment. Start my free trial
$180.00 without a subscription
+ $20.00 shipping, free from 2 items
Format
This size covers 5 weeks · $24 per week as a VIP member, at the minimum dose.
You will need more needle tips: your protocol calls for 15 injections, the tips in the box cover 12.
1 to 2 business days in Quebec and Ontario
In stock
Good to know: not for use during pregnancy, with a history of pancreatitis or thyroid cancer, or with an eating disorder.
Add 1 item and shipping is free (from 2 items).
Recommended supplies
- Embouts d'aiguille, paquet de 50A fresh needle tip for every injection$16.00
- Tampons d'alcool, boîte de 25To disinfect before injecting$6.00
- Combo embouts et tamponsNeedle tips and swabs together$20.00
What to combine it with?
Pick one to three products: the text follows your combination.
Two angles on metabolism
What each one brings
- Retatrutide : It regulates the signals of appetite and blood sugar by activating three receptors, GLP-1, GIP and glucagon.
- MOTS-c : It is studied for how cells use their reserves, through AMPK, the exercise enzyme.
Why together
Retatrutide acts on what comes in, appetite and satiety; MOTS-c on what the cells do with the energy available. Two angles on the same metabolism, brought together in Peptiva's DELTA stack.
What adds up
- Up to 28.7% of body weight on average in retatrutide's TRIUMPH-4 trial, with a second lever inside the cells.
- The endurance and steady energy MOTS-c users report, while appetite settles.
In practice
Two pens, two protocols: retatrutide keeps its own, MOTS-c follows the one on its page.
When will I feel the effects?
Week 1
Getting started
Your body is discovering the product. Noticing nothing in this first week is perfectly normal.
Weeks 2 to 4
Appetite settles down
Many people report feeling full sooner and having fewer cravings in the first few weeks.
Weeks 5 to 12
The rhythm settles in
The dose goes up in steps and consistency does its work. This is often when the change starts to show.
Week 13 and up
Time to take stock
Most of it builds over several months. Compare with your starting point before deciding what comes next.
These timings vary from one person to the next. This timeline is a guide, not a promise.
More info
Is it for me?
People choose it for weight loss: up to 28.7% of body weight on average in the TRIUMPH-4 phase 3 trial.
Not for you if:
- Pregnancy, breastfeeding, or planning a pregnancy.
- Personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2 (a warning that applies to the whole GLP-1 class).
- History of pancreatitis.
- Type 1 diabetes, or type 2 diabetes on insulin without medical supervision.
- A current or past eating disorder.
- Minors.
- Any medication whose absorption depends on stomach emptying (oral contraceptives, certain thyroid treatments): discuss it with your doctor.
Price per week
- 9 mg$24 per week as a VIP member · $30 without a subscription
- 14 mg$41 per week as a VIP member · $52 without a subscription
- 19 mg$48 per week as a VIP member · $60 without a subscription
- 29 mg$53 per week as a VIP member · $66 without a subscription
- Montée complète : 4 stylos (9 + 14 + 19 + 29 mg)$39 per week as a VIP member · $48 without a subscription
At the protocol's minimum dose. Quantity discounts lower this figure further.
How to use
The box
- Ready in one step: the included water syringe is already measured for this pen.
- In the box: the pen, its pre-measured water syringe, 12 needle tips (a new one for each injection) and the alcohol swabs.
- The Peptiva system: powder sealed without air or light, intact down to the last dose. Sealed until you: the box is shrink-wrapped at Peptiva, you are the first person to open it. Pen or vial: the difference
- Shipped from Quebec by Xpresspost, 1 to 2 business days in Quebec and Ontario*, with tracking. Replacement if your package is lost.
- Analyzed by Sidechain, independent laboratory · see the certificate.
- Pen with a defective mechanism: our team assesses it, and replaces it at no charge if the defect is confirmed. See the details.
Shipping
- More items, more value: shipping ($20.00) is on us from 2 items (anywhere in Canada), then 3 items −5%, 4 to 5 items −8%, 6 items or more −10% off your cart, except NAD+, glutathione and the full ramp-up, which already carry their quantity price. Stacks with your member discount. A complete stack counts as 1 more item.
- Read the full educational profile : description and how to use it, in the Centre.
Storage
Good for 6 weeks after reconstitution, if it has been kept properly: in the fridge, away from light, with an alcohol swab on the tip before each use. Past that, we do not recommend using it, even if some is left; if the liquid turns cloudy or changes colour, do not use it, even before.
VIP membership
$36.00 off this item (20% off all year), plus shipping at $10 instead of $20: the membership pays for itself by your 3rd order.
See all 3 benefits
- Member: this protocol becomes a dose schedule in your account, with its days, its reminder time and the tracking of your effects, and, when the time comes, your tapering step by step.
- Your training and meal plans: built from your answers, with every exercise shown on video, every meal with its calories and macros, and your grocery list.
- Victor, your VIP butler: he adjusts your dose, your days and your plans; you confirm with one click.
Membership$119· 12 months· free from $649
Scientific studies5 studies
2026 · Jastreboff et al., New England Journal of Medicine (TRIUMPH-1) · Placebo-controlled phase 3 trial, 2,339 adults living with obesity, followed for 80 weeks
Average weight loss of up to 25.0% of initial body weight at the highest dose, versus 3.9% on placebo, according to the publication. Adverse effects were mostly digestive, as in phase 2; skin tingling (dysesthesia) was reported more often than on placebo.
2025 · Eli Lilly, press release of December 11, 2025 (TRIUMPH-4) · Placebo-controlled phase 3 trial, 445 adults living with obesity and knee osteoarthritis, followed for 68 weeks
Average weight loss of 28.7% at the highest dose in participants who kept taking it (23.7% counting all randomized participants), versus 2.1% on placebo by the same calculation. Results announced by the manufacturer, not yet published in a journal.
2024 · Sanyal et al., Nature Medicine · Phase 2 substudy, adults with obesity and fatty liver disease
Liver fat measured by MRI reduced by up to 82% at 24 weeks, and back below the normal 5% threshold in up to 86% of participants at the higher doses.
2023 · Jastreboff et al., New England Journal of Medicine · Randomized placebo-controlled trial, 338 adults living with obesity
Average weight loss of up to about 24% of initial body weight at the highest dose, versus about 2% on placebo. Adverse effects were mostly digestive and more frequent during dose escalation.
2023 · Rosenstock et al., The Lancet · Randomized phase 2 trial, adults with type 2 diabetes
Greater improvement in glycemic control (HbA1c) and greater weight loss than with dulaglutide, a reference GLP-1 drug.
Chemical identityCAS No. 2381089-83-2
LY3437943
- Form
- Acylated peptide (fatty acid chain), values for the base form
- CAS No.
- 2381089-83-2
Salt form: as stated on the lot's certificate of analysis.
Certificate of analysis
The Peptiva system
From the box to the first injection, in three steps.
1. Receive
The pen and its water syringe arrive in the same box.
2. Empty the syringe
One gesture, once: the water goes into the pen, the plunger moves back.
3. Set the dial
For each injection, a new needle tip and the dose on the dial, with nothing to measure.
The protocol comes with the product
Dosage, cycle length, storage and injection technique, written for this product. Get it right now, even before you order.
Where to find it: The QR code on your box label · In My account, as soon as the order is paid · In the payment confirmation email
Get the protocol by email
A Peptiva account is required: the full protocol is sent to that account's email as soon as it exists.
Frequently asked questions about this product
What if my package never arrives?+
How does the personalized Peptiva plan work?+
What is a peptide and how does it work in the body?+
Pair it with
Stack · Weight loss
Two mechanisms
Retatrutide acts on appetite and blood sugar, 5-Amino-1MQ inside fat cells: two different mechanisms for the same goal.
- Retatrutide9 mgCovers 5 weeks · $24 per week as a VIP member, at the minimum dose$180.00
- 5-Amino-1MQ125 mgCovers 3 and a half weeks · $36 per week as a VIP member, at the minimum dose$247.00
or $324.52 as a VIP member
Quantity discount included ($21.35). Free shipping.
Building a stack counts as one more item toward the quantity discount.
Each product keeps the protocol on its own page. Educational information, not medical advice: before combining products, talk to a health professional.
* Xpresspost transit time for most areas of Quebec and Ontario, counted from shipping and not from the order. Allow 2 to 4 business days elsewhere in Canada. Shipping details.